Glaucocalyxin B
CAS No. 80508-81-2
Glaucocalyxin B ( —— )
Catalog No. M29628 CAS No. 80508-81-2
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 329 | Get Quote |
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100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGlaucocalyxin B
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NoteResearch use only, not for human use.
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Brief DescriptionGlaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).
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DescriptionGlaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).(In Vitro):Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells (IC50s: 6.15 and 5.86 μM at 24 h). Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis and autophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose-dependent manner. GlnB increases the apoptotic cell population and enhanced poly (ADP ribose) polymerase 1 cleavage .
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number80508-81-2
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Formula Weight374.5
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Molecular FormulaC22H30O5
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Purity>98% (HPLC)
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Solubility——
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SMILES[H][C@@]12CCC3[C@@H](OC(C)=O)[C@@]1(C(O)C[C@]1([H])C(C)(C)C(=O)CC[C@@]21C)C(=O)C3=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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